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In the realm of aesthetic treatments, a surprising new trend has emerged involving facial injections derived from fish sperm DNA. While the concept might sound unusual, this innovative procedure utilizes tiny fragments of DNA called polynucleotides, extracted from trout or salmon sperm, rather than pure fish sperm itself. These polynucleotides are introduced into the skin with the aim of stimulating the body’s cells to produce more collagen and elastin—key proteins responsible for maintaining skin’s firmness and elasticity. For individuals like Abby Warnes, who recently underwent this treatment in Manchester, the goal is to rejuvenate her skin and mitigate the effects of long-standing acne by reducing redness and scarring.
Polynucleotides have been gaining attention in skincare circles and celebrity endorsements, sparking curiosity about their potential transformative effects. Pop star Charli XCX shared on Instagram that she has moved away from traditional fillers in favor of these “deep vitamins” for the skin. Similarly, members of the Kardashian family and Jennifer Aniston have praised the results, with Aniston humorously attributing her radiant complexion to “salmon skin.” Their endorsements have helped popularize what proponents hail as a breakthrough in regenerative skincare, contrasting with conventional approaches like fillers.
Suzanne Mansfield from Dermafocus, an aesthetics company, likens the effect of polynucleotides to a “Benjamin Button moment,” referencing the movie character who ages backwards. Though such dramatic rejuvenation is unlikely, early clinical research indicates that injecting polynucleotides can improve skin hydration, reduce fine lines and wrinkles, and decrease scarring. Mansfield emphasizes that these injections work by enhancing natural skin processes, encouraging a healthier and potentially fresher complexion. However, treatments do come with a significant cost, typically ranging from £200 to £500 per session, with multiple treatments required over time to maintain results.
Despite the enthusiasm, some medical experts remain cautious. Dermatologist Dr. John Pagliaro from Australia highlights the limited evidence available, questioning whether fish DNA fragments can be as effective as the body’s own nucleotides. Concerns also arise from cases like that of Charlotte Bickley, who experienced adverse effects such as skin infection and increased dark circles following polynucleotide injections. Experts warn about possible side effects including redness, swelling, allergic reactions, and longer-term complications if the injections are improperly administered. While these products are used widely in the UK and registered with regulatory bodies as medical devices, they have yet to receive approval comparable to that of medicines, such as by the US FDA. Industry figures like Ashton Collins and Dr. Sophie Shotter advocate for stricter regulation and quality control to ensure patient safety, acknowledging that while polynucleotides may offer benefits, they are not a universal solution for every skin concern
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