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Recent research reveals that individuals discontinuing weight-loss injections, such as Mounjaro or Wegovy, experience weight regain at a rate four times faster than those who have stopped traditional dieting and exercise. According to findings published in the British Medical Journal, people using these medications typically lose around 20% of their body weight but, after stopping treatment, gain back approximately 0.8 kilograms each month. As a result, most return to their original weight within about 18 months.
Dr. Susan Jebb of Oxford University, who conducted the study, cautions that potential users should be aware of this rapid weight regain after stopping the injections. She also emphasized that these results stem from clinical trial data rather than real-world evidence, indicating a need for further research into the long-term effects of these newer slimming drugs. The analysis covered 37 studies with over 9,000 participants, comparing weight-loss injections with conventional dieting or other medications. Notably, only eight studies involved the newer GLP-1 receptor agonists like Wegovy and Mounjaro, and these had follow-up periods that lasted no longer than one year after treatment cessation, meaning the weight regain estimates are preliminary.
In contrast, individuals who lose weight through diet and exercise tend to regain pounds more slowly, at a rate closer to 0.1 kilograms per month, although this varies widely. The National Health Service (NHS) recommends these injections specifically for people who are overweight and facing obesity-related health risks, rather than for those simply aiming to slim down. Healthcare providers are encouraged to combine drug prescriptions with lifestyle changes such as healthier eating habits and increased physical activity to support sustained weight loss. Many experts argue that because of the high risk of relapse, treatment with these medications may need to be lifelong.
Patients who have stopped using the injections report intense hunger signals, describing the experience as flipping a switch that triggers sudden and overwhelming appetite. One woman explained, “It was like something opened up in my mind and said: ‘Eat everything, go on, you deserve it because you haven’t eaten anything for so long.'” Nutrition specialist Dr. Adam Collins from the University of Surrey notes that the underlying mechanism may involve how these drugs mimic the hormone GLP-1, which naturally regulates hunger. Prolonged artificial stimulation could lead to reduced natural GLP-1 production and diminished sensitivity, making it harder to control appetite once the medication is withdrawn. He warns that quitting these drugs abruptly can be especially challenging if patients have not adopted lasting dietary or behavioral changes, relying solely on the medication’s appetite suppression
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